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EAE model


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“Ž–Źd‰ťÇƒ‚ƒfƒ‹
Ž‰ŽżˆŮíÇƒ‚ƒfƒ‹

ƒqƒg‰‘ă×–E”|—{Œn

ŒŒŠÇVśƒ‚ƒfƒ‹

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Ä‹ˇóƒ‚ƒfƒ‹

‘ăŽÓŤŽžŠłƒ‚ƒfƒ‹

”畆Œn•a‘Ôƒ‚ƒfƒ‹

‰ŠÇŤ’°ŽžŠłƒ‚ƒfƒ‹

‘@ˆŰÇƒ‚ƒfƒ‹

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Cell-based in vitro models

Biomarker Assay List

Oncology

siRNA target validation

Experimental Autoimmune Encephalomyelitis (EAE):

Ą@Model in SJL mouse
Ą@Model in C57BL/6 mouse
Ą@Model in the DA rat


Žĺ‚ČŽŔŃ: 1,25-dihydroxyvitamin D3, anti-MIP-1ƒż, anti-CD40L, IL-10,
TNFR-IgG, Linomide, anti-integrin-ƒż4, etc.


Recent papers:
Soluble Mannosylated Myelin Peptide Inhibits the Encephalitogenicity of
@@Autoreactive T cells during EAE. American Journal of Pathology, Jan-07

Protective and Therapeutic role for ƒżB-crystallin in autoimmune
@@demyelination, nature, 2007

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Posters related to CNS research

PET-CT imaging to measure P-gp and Bcrp1 mediateddrug-drug interactions at Blood-Brain Barrier

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